Surface proteins of Gram-positive pathogens are key determinants of virulence that substantially shape host-microbe interactions.Specifically, these proteins mediate host invasion and pathogen transmission, drive the acquisition of heme-iron from hemoproteins, and subvert innate and adaptive immune cell responses to push bacterial survival and path

In recent years, a wide variety of Machine Learning (ML) algorithms, including Deep Learning (DL) methods, have been proposed for electrocardiogram (ECG) beat classification.However, accurately Needles discerning ECG beat types faces challenges due to noise interference and inherent imbalances among different classes.Moreover, understanding mathema

Functional interactions between G protein-coupled receptors are poised to enhance neuronal sensitivity to neuromodulators and therapeutic drugs.Mu and delta opioid receptors (MORs and DORs) can interact when overexpressed in the same cells, but whether co-expression of SOOTHE SHAMPOO endogenous MORs and DORs in neurons leads to functional interacti

Summary: At presynaptic terminals, neurotransmitters are released by synaptic vesicle exocytosis at the active zone.In order to maintain efficient neurotransmission and proper synaptic structure, sites of vesicle fusion must be cleared rapidly by endocytosis.Therefore, the coupling of exo- and endocytosis is crucial.Despite many years of research,